Hormone Therapy, Genotype & Memory
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ON THE IMAGE
Alzheimer's reaches the entorhinal cortex before it reaches the hippocampus.

CAPTION
There's a reason researchers measured this specific part of the brain.

The entorhinal cortex is one of the first regions affected by Alzheimer's-related change, often before the hippocampus. Reduction in entorhinal volume has been shown to predict progression from mild cognitive impairment to Alzheimer's better than hippocampal volume.

In this cohort, APOE4 carriers using hormone therapy had larger entorhinal volumes than APOE4 non-users — in the region where the earliest changes tend to show up.

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Educational content, not medical advice — individual results and risks vary.

HASHTAGS
#menopause #womenshealth #brainhealth #memory #hormonetherapy

SUPPORTING EVIDENCE
Discussion: entorhinal cortex is one of the first regions affected by AD-related pathological changes, even before the hippocampus; reduction considered a better predictor than hippocampus volumes in conversion from MCI to AD.
